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pathscan cleaved notch1 sandwich elisa kit  (Cell Signaling Technology Inc)
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Cell Signaling Technology Inc pathscan cleaved notch1 sandwich elisa kit
Fig. 3 Intra-articular injection of LPS activates Notch signaling in knee-innervating DRG of naïve mice. A Knee hyperalgesia 24-h time-course after IA injection of LPS (3 μg) or vehicle in 10-week old naïve mice (N = 6 mice per group). 450 g is the threshold baseline for naïve mice (dashed line). B Gene expression of Adam17, Rbpj, Hes1, Jag1, and <t>Notch1</t> in the ipsilateral L3-L5 DRGs 4 h after IA injection of LPS or vehicle (N = 6 mice per group). C Protein levels of NICD in the pooled L3-L5 DRG tissue lysates 24 h after IA injection of LPS or vehicle (N = 4 mice per group). NICD levels are presented as absorbance value at 450 nm normalized to total protein (A450/mg total protein). D Gene expression of Ccl2 in DRG 4 h after IA injection of LPS or vehicle (N = 6 mice per group). E Protein levels of CCL2 in DRG tissue lysates 24 h after IA injection of LPS or vehicle (N = 4 mice per group). CCL2 levels are presented as CCL2 protein normalized to total protein (pg CCL2/mg total protein)
Pathscan Cleaved Notch1 Sandwich Elisa Kit, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Fig. 3 Intra-articular injection of LPS activates Notch signaling in knee-innervating DRG of naïve mice. A Knee hyperalgesia 24-h time-course after IA injection of LPS (3 μg) or vehicle in 10-week old naïve mice (N = 6 mice per group). 450 g is the threshold baseline for naïve mice (dashed line). B Gene expression of Adam17, Rbpj, Hes1, Jag1, and Notch1 in the ipsilateral L3-L5 DRGs 4 h after IA injection of LPS or vehicle (N = 6 mice per group). C Protein levels of NICD in the pooled L3-L5 DRG tissue lysates 24 h after IA injection of LPS or vehicle (N = 4 mice per group). NICD levels are presented as absorbance value at 450 nm normalized to total protein (A450/mg total protein). D Gene expression of Ccl2 in DRG 4 h after IA injection of LPS or vehicle (N = 6 mice per group). E Protein levels of CCL2 in DRG tissue lysates 24 h after IA injection of LPS or vehicle (N = 4 mice per group). CCL2 levels are presented as CCL2 protein normalized to total protein (pg CCL2/mg total protein)

Journal: Arthritis research & therapy

Article Title: Notch signaling is activated in knee-innervating dorsal root ganglia in experimental models of osteoarthritis joint pain.

doi: 10.1186/s13075-023-03039-1

Figure Lengend Snippet: Fig. 3 Intra-articular injection of LPS activates Notch signaling in knee-innervating DRG of naïve mice. A Knee hyperalgesia 24-h time-course after IA injection of LPS (3 μg) or vehicle in 10-week old naïve mice (N = 6 mice per group). 450 g is the threshold baseline for naïve mice (dashed line). B Gene expression of Adam17, Rbpj, Hes1, Jag1, and Notch1 in the ipsilateral L3-L5 DRGs 4 h after IA injection of LPS or vehicle (N = 6 mice per group). C Protein levels of NICD in the pooled L3-L5 DRG tissue lysates 24 h after IA injection of LPS or vehicle (N = 4 mice per group). NICD levels are presented as absorbance value at 450 nm normalized to total protein (A450/mg total protein). D Gene expression of Ccl2 in DRG 4 h after IA injection of LPS or vehicle (N = 6 mice per group). E Protein levels of CCL2 in DRG tissue lysates 24 h after IA injection of LPS or vehicle (N = 4 mice per group). CCL2 levels are presented as CCL2 protein normalized to total protein (pg CCL2/mg total protein)

Article Snippet: Protein levels of NICD, the active form of Notch protein, in L3-L5 DRG from mice 12 or 26 weeks after DMM or sham surgery (N = 4–7 mice per group) were assessed using PathScan Cleaved Notch1 Sandwich ELISA Kit (Cell Signaling Technology, Danvers, MA) following the manufacturer’s instructions.

Techniques: Injection, Gene Expression

Fig. 6 Notch signaling genes are expressed in DRG neurons after DMM surgery. RNA in situ hybridization analysis of Jag1 (A), Hes1 (B), and Notch1 (C) in the L4-DRG of mice 26 weeks after DMM or sham surgery. Representative images of each group are shown (N = 3 mice per group). Scale bars, 25 μm. RNA expression in the neurons was quantified using H-score

Journal: Arthritis research & therapy

Article Title: Notch signaling is activated in knee-innervating dorsal root ganglia in experimental models of osteoarthritis joint pain.

doi: 10.1186/s13075-023-03039-1

Figure Lengend Snippet: Fig. 6 Notch signaling genes are expressed in DRG neurons after DMM surgery. RNA in situ hybridization analysis of Jag1 (A), Hes1 (B), and Notch1 (C) in the L4-DRG of mice 26 weeks after DMM or sham surgery. Representative images of each group are shown (N = 3 mice per group). Scale bars, 25 μm. RNA expression in the neurons was quantified using H-score

Article Snippet: Protein levels of NICD, the active form of Notch protein, in L3-L5 DRG from mice 12 or 26 weeks after DMM or sham surgery (N = 4–7 mice per group) were assessed using PathScan Cleaved Notch1 Sandwich ELISA Kit (Cell Signaling Technology, Danvers, MA) following the manufacturer’s instructions.

Techniques: RNA In Situ Hybridization, RNA Expression